Ketamine: Is It Pro-Epileptic or Anti-Epileptic? The Debate Continues. A Narrative Review with a Case Discussion

Ketamine is one of the old anaesthetic agents which has regained popularity in analgesia, trauma, emergency medicine, neurology and psychiatry. Recently several cases were reported on ketamine induced seizures otherwise healthy children despite its treatment refractory status epilepticus. We present an eight-year-old prematurely born boy who developed two episodes generalized tonic clonic following administration for a short ophthalmic procedure. This case our comprehensive narrative review literature pro- anti-epileptic effects show that debate continues gaps mechanism action, etiology risk factors ketamine’s epileptic activity remains. Due to recent increase use further evaluation warranted ensure safe effective ketamine.